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. 2020 Nov 23;14:593248. doi: 10.3389/fnins.2020.593248

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Copyright © 2020 Wu, Yao, Dwivedi, Negraes, Zhao, Wang, Trujillo, Muotri and Haddad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of variability in neuronal membrane properties. (A) Representative images of whole-cell patch clamp recording of a neuron at the edge of cortical organoids. Scale bar, 200 μm (upper panel) and 10 μm (lower panel). (B,C) Plots of cell capacitance (C_m), and AP amplitude (evoked by 50 pA) of individual neurons from three healthy subjects (subj-1, subj-2, and subj-3) for 12-week and 16-week old organoids. For both panels, one-way ANOVA, p > 0.99 for comparisons among three subjects at 12-week, or 16-week. n = 5–12 neurons. (D) Plot of peak I_Na density of individual neurons from three healthy subjects at the age of 12-week and 16-week. One-way ANOVA, p = 0.36. n = 5–11 neurons. (E) Plot of peak I_K density of individual neurons. One-way ANOVA, p = 0.73. n = 5–11 neurons. Recording protocols for I_Na and I_K were shown in Figures 5, 6. Graphs display mean and SEM.