Table 5.

Logistic regression modeling evaluating risk factors for severe COVID-19 in middle-aged (40–59 years) patients without comorbidities

Variables	Univariate logistic regression			Multivariate logistic regression
	OR	95% CI	p valuea	OR	95% CI	p valuea
Fever > 39℃	3.648	1.221–10.905	< 0.001
Myalgia	4.850	0.986–23.846	0.052
Dyspnea	5.803	1.780–18.919	0.004
White blood cell count	1.229	1.049–1.440	0.011
Neutrophil count	1.297	1.097–1.533	0.002
Lymphocyte count	0.045	0.008–0.253	< 0.001
NLR	1.245	1.132–1.368	< 0.001	1.238	1.110–1.382	< 0.001
Platelet count	0.996	0.990–1.002	0.156
D-dimer > 1 μg/ml	16.121	4.246–61.210	< 0.001	16.079	3.162–81.775	0.001
ALT	1.006	0.999–1.013	0.088
Albumin	0.828	0.710–0.965	0.016
LDH	1.007	1.002–1.011	0.003
Procalcitonin	1.753	0.106–28.863	0.695
SOFA	1.854	1.268–2.711	0.001

COVID-19 coronavirus disease 2019, OR Odds Ratio, CI confidence interval, NLR neutrophil to lymphocyte ratio, ALT alanine amino transferase, LDH lactate dehydrogenase, SOFA Sequential Organ Failure Assessment

^ap < 0.05 was considered statistically significant