Table 2.
Comparison of respiratory mechanics and PEEP titration in supine position, for patients with acute respiratory distress syndrome induced or not by coronavirus disease-19
| C-ARDS (n = 17) | NC-ARDS (n = 13) | p value | |
|---|---|---|---|
| Respiratory mechanics | |||
| Respiratory rate (breath/min) | 30 [28, 35] | 31 [29, 31] | 0.74 |
| Tidal volume (ml/kg of PBW) | 6.1 [5.9, 6.3] | 6.2 [6.0, 6.3] | 0.58 |
| CRS at low PEEP (mL/cmH2O) | 40 [32, 47] | 35 [26, 38] | 0.07 |
| Airway opening pressure (cmH2O) | 2 [0, 4] | NA | |
| Recruitment-to-inflation ratio | 0.46 [0.33, 0.52] | NA | |
| PaO2/FiO2 before EIT explorations (mmHg) | 133 [96, 180] | 120 [110, 137] | 0.40 |
| EIT-PEEP titration | |||
| Best PEEPa (cmH2O) | 12 [9, 12] | 9 [6, 9] | < 0.01 |
| Hyperdistension at PEEP 18 cmH2O, % | 24 [17, 30] | 35 [25, 41] | 0.02 |
| AUC for hyperdistension | 111 [68, 136] | 193 [119, 226] | 0.03 |
| Collapse at PEEP 6 cmH2O, % | 27 [20, 35] | 13 [7, 19] | < 0.01 |
| AUC for collapse | 94 [59, 141] | 45 [31, 61] | < 0.01 |
aDefined using EIT as the smallest sum of hyperdistension and collapse. Continuous variables are expressed as median [interquartile range]
C-ARDS coronavirus disease-19-related acute respiratory distress syndrome, NC-ARDS noncoronavirus disease-19-related acute respiratory distress syndrome, PBW predicted body weight, CRS respiratory system compliance, PEEP positive end-expiratory pressure, EIT electrical impedance tomography, AUC area under the curve, NA not available