Table 3.
Comparison of patients with coronavirus disease-19-related acute respiratory distress syndrome associated with lower versus higher respiratory system compliance
| Compliance ≥ 40 mL/cmH2O (n = 9) | Compliance < 40 mL/cmH2O (n = 8) | p value | |
|---|---|---|---|
| Body mass index (kg/m2) | 29.8 [27.9, 33.1] | 30.3 [24.4, 33.4] | 0.67 |
| Time from first symptoms to exploration (days) | 9 [6.5, 12] | 10 [9, 11] | 0.63 |
| PaO2/FiO2 before EIT (mmHg) | 138 [89, 182] | 130 [118, 150] | 0.96 |
| Respiratory system compliance (mL/cmH2O) | 47 [46, 52] | 31.5 [29, 37] | < 0.01 |
| Recruitment-to-inflation ratio | 0.48 [0.41, 0.62] | 0.4 [0.31, 0.49] | 0.25 |
| Increase in PaO2/FiO2 after proning (mmHg) | 52.5 [38, 91] | 52 [12, 68] | 0.53 |
| Duration of proning (h) | 18.5 [18, 21] | 18 [17.5, 20.5] | 0.87 |
| EIT-PEEP titration | |||
| Best PEEPa (cmH2O) | 12 [12] | 12 [9, 13.5] | 0.92 |
| AUC for compliance | 444 [345, 513] | 293 [260, 316] | < 0.01 |
| Hyperdistension at PEEP 18 (%) | 23 [17, 31] | 25 [18, 27] | 0.70 |
| AUC for hyperdistension | 111 [68, 141] | 108 [78, 131] | 0.81 |
| Collapse at PEEP 6 (%) | 29 [21, 39] | 24 [19 – 31] | 0.61 |
| AUC for collapse | 104 [59, 141] | 78 [66, 115] | 0.74 |
aDefined using EIT as the smallest sum of hyperdistension and collapse. Continuous variables are expressed as median [interquartile range]
PEEP positive end-expiratory pressure, EIT electrical impedance tomography, AUC area under the curve