Table 2.

Clinical characteristics of patients.

	Patients without cognitive impairment (n = 23)	Patients with cognitive impairment (n = 37*)	p
Age at onset (years)	55.91 ± 7.92	58.54 ± 10.02	0.62
Disease duration (months)	56.54 ± 38.32	62.01 ± 36.03	0.73
Deceased patients	13	16	0.52
Phenotype MSA P/C	10/13	19/18	0.51
MSA-P Possible	3	2
MSA-P Probable	7	17
MSA-C Possible	1	4
MSA-C Probable	12	14
Parkinsonism	16	27	0.22
Cerebellar signs	17	28	0.96
Pyramidal signs	15	25	0.74
OH	17	27	0.26
Urinary disturbances	18	30	0.65
RBD	12#	23	0.26
OSAS	5	8	0.34
Stridor	6	9	0.58
Dysarthria	8	12	0.67
Disease severity			0.08
0	7	10
1	7	6
2	3	12
3	6	2
4	0	3
5	0	2

MSA, multiple system atrophy; P, parkinsonian type; C, cerebellar type; OH, orthostatic hypotension; RBD, REM sleep behavior disorder; OSAS, obstructive sleep apnea syndrome. 0–5: number of milestones of progression.

^*The number includes patients with dementia (n = 6).

^#Two patients showed RSWA (REM sleep without atonia) at video polysomnography.