Table 2.
Clinical characteristics of patients.
|
Patients without cognitive impairment (n = 23) |
Patients with cognitive impairment (n = 37*) |
p | |
|---|---|---|---|
| Age at onset (years) | 55.91 ± 7.92 | 58.54 ± 10.02 | 0.62 |
| Disease duration (months) | 56.54 ± 38.32 | 62.01 ± 36.03 | 0.73 |
| Deceased patients | 13 | 16 | 0.52 |
| Phenotype MSA P/C | 10/13 | 19/18 | 0.51 |
| MSA-P Possible | 3 | 2 | |
| MSA-P Probable | 7 | 17 | |
| MSA-C Possible | 1 | 4 | |
| MSA-C Probable | 12 | 14 | |
| Parkinsonism | 16 | 27 | 0.22 |
| Cerebellar signs | 17 | 28 | 0.96 |
| Pyramidal signs | 15 | 25 | 0.74 |
| OH | 17 | 27 | 0.26 |
| Urinary disturbances | 18 | 30 | 0.65 |
| RBD | 12# | 23 | 0.26 |
| OSAS | 5 | 8 | 0.34 |
| Stridor | 6 | 9 | 0.58 |
| Dysarthria | 8 | 12 | 0.67 |
| Disease severity | 0.08 | ||
| 0 | 7 | 10 | |
| 1 | 7 | 6 | |
| 2 | 3 | 12 | |
| 3 | 6 | 2 | |
| 4 | 0 | 3 | |
| 5 | 0 | 2 |
MSA, multiple system atrophy; P, parkinsonian type; C, cerebellar type; OH, orthostatic hypotension; RBD, REM sleep behavior disorder; OSAS, obstructive sleep apnea syndrome. 0–5: number of milestones of progression.
*
The number includes patients with dementia (n = 6).
#
Two patients showed RSWA (REM sleep without atonia) at video polysomnography.