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. 2020 Nov 23;11:605085. doi: 10.3389/fimmu.2020.605085

Figure 3.

Figure 3

Superposition of pBF2*1501 with other known chicken pMHC-I structures, representative mammal pMHC-I structures and cCD8αα/pBF2*1501 and cCD8αα/pBF2*0401 complexes. (A) Superimposed Cα traces of chicken BF2*1501-RY0808-β2m (green), pBF2*0401 (PDB code: 4E0R, cyan), pBF2*2101 (PDB code: 3BEV, light blue), pBF2*1401 (PDB code: 4CW1, purple), and pBF2*1201 (PDB code: 5YMV, brown). (B) Cα-trace comparison of BF2*1501-RY0808-β2m (green), HLA-A*0201 (PDB code: 1HHK, cyan), H-2Kb (PDB code: 1G7Q, blue), SLA-1*0401 (PDB code: 3QQ3, light purple), and BoLA-N*01801 (PDB code: 3PWU, light red), with an enlarged view of the CD loop in the gray box. (C) Overlap between free pBF2*1501 and pBF2*1501 of cCD8αα/pBF2*1501 and between free pBF2*0401 and pBF2*0401 of cCD8αα/pBF2*0401, based on the α1 and α2 domains, respectively. Enlarged views of the overlapped peptides are shown in the dotted red box and dotted orange box for cCD8αα/pBF2*1501 and cCD8αα/pBF2*0401, respectively; an enlarged view of the overlapped α3 domain CD loop is shown in the red box and orange box for cCD8αα/pBF2*1501 and cCD8αα/pBF2*0401. Free pBF2*1501, pBF2*1501 of cCD8αα/pBF2*1501 complex A, pBF2*1501 of cCD8αα/pBF2*1501 complex B, free pBF2*0401, pBF2*0401 of cCD8αα/pBF2*0401 complex A and pBF2*0401 of cCD8αα/pBF2*0401 complex B are colored green, yellow, light pink, cyan, orange, and light blue, respectively.