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. 2020 Nov 23;11:605085. doi: 10.3389/fimmu.2020.605085

Figure 7.

Figure 7

Contact residue conservation analysis among cCD8αα/pBF2*1501 complex B, cCD8αα/pBF2*0401 complex B, hCD8αα/pHLA-A*0201, mCD8αα/pH-2Kb complexes. (A) Conservation analysis of contact residues between cCD8αα/pBF2*1501 complex B and the hCD8αα/pHLA-A*0201 complex. The alignment between pBF2*1501 and pHLA-A*0201 is shown at the top, and the alignment between cCD8αα and hCD8αα is shown below. All contact residues are shown in stick representation and labeled by three-letter abbreviation. The contact residues of pBF2*1501 and pHLA-A*0201 are colored pink and light brown, and the cyan rectangle represents the α2 domain, while the pink rectangle represents the α3 domain. The contact residues of the cCD8α1 and cCD8α2 subunits are colored light brown and orange, and the contact residues of the hCD8α1 subunit and hCD8α2 subunit are colored gray and brown. The light pink circle represents the CD8α1 subunit, and the light-blue circle represents the CD8α2 subunit. (B) Conservation analysis of contact residues between cCD8αα/pBF2*1501 complex B and the mCD8αα/pH-2Kb complex. The alignment between pBF2*1501 and pH-2Kb is shown at the top, and the alignment between cCD8αα and mCD8αα is shown below. All contact residues are shown in stick representation and labeled by three-letter abbreviation. The contact residues of pBF2*1501 and pH-2Kb are colored pink and dark gray, and the cyan rectangle represents the α2 domain, while the pink rectangle represents the α3 domain. The contact residues of the cCD8α1 subunit and cCD8α2 subunit are colored light brown and orange, and the contact residues of the mCD8α1 subunit and mCD8α2 subunit are colored light red and light pink. The light-pink circle represents the CD8α1 subunit, and the light-blue circle represents the CD8α2 subunit. (C) Conservation analysis of contact residues between cCD8αα/pBF2*1501 complex B and cCD8αα/pBF2*0401 complex B. The alignment between pBF2*1501 and pBF2*0401 is shown at the top, and the alignment of cCD8αα is shown below. All contact residues are shown in stick representation and labeled by three-letter abbreviation. The contact residues of pBF2*1501 and pBF2*0401 are colored pink and blue, and the cyan rectangle represents the α2 domain, while the pink rectangle represents the α3 domain. The contact residues of the cCD8α1 subunit and the cCD8α2 subunit of cCD8αα/pBF2*1501 complex B are colored light brown and orange, and the contact residues of the cCD8α1 and cCD8α2 subunits of cCD8αα/pBF2*0401 complex B are colored deep green and pink. The light-pink circle represents the CD8α1 subunit, and the light-blue circle represents the CD8α2 subunit.