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Design of PGS-based bio-artificial matrices. (A) Bioactive ligands RGD peptide, QK peptide are mono-PEG-acrylated for covalent crosslinking into PGS network. Addition of a photoinitiator to PGS aqueous solution of PGS followed by 10 min UV irradiation results in crosslinking of hydrogel through free radical polymerization of acrylate end groups before and after lyophilization. (B) Gross image of L-PGS-P. (C) SEM image of L-PGS-P. (D) Synthesis of poly (glycerol sebacate) polymer.
