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. 2020 Nov 23;10:601055. doi: 10.3389/fonc.2020.601055

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Copyright © 2020 Fang, Zhang, Wang, Wei, Wu, Mou, Zhang, Liang and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNA AFAP1-AS1 is a marker for poor prognostic outcomes in NPC patients. (A) AFAP1-AS1 expression in NPC cells and nasopharyngeal epithelial cells. (B) Compared with paired nontumor specimens, AFAP1-AS1 expression is upregulated in freshly frozen NPC tumor tissues. (C) Representative images of AFAP1-AS1 expression in paraffin-embedded NPC tumors and paired adjacent nontumor specimens detected using RNAscope. Scale bars: 50 µm. (D) Quantification of AFAP1-AS1 expression in (C). (E) Kaplan-Meier analysis of overall survival (OS) in NPC patients with high vs. low AFAP1-AS1 expression. (F, G) AFAP1-AS1 is expressed in both the nucleus and cytoplasm of NPC cells as detected using qRT-PCR. Error bars represent the standard deviation for each value. *P < 0.05. ***P < 0.001. The data represent three independent experiments. lncRNA, long noncoding RNA.