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. 2020 Sep 25;82(11):1648–1654. doi: 10.1292/jvms.20-0034

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©2020 The Japanese Society of Veterinary Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 1. — Changes in the 50% response threshold to mechanical stimulation in oxaliplatin administration in Experiment 1. (Note: From day 0 to 13, only Oxaliplatin (OXL) was administered. Phosphate buffered saline (PBS), recombinant human lactoferrin (rhLF) and recombinant human lactoferrin Fc fusion (rhLF-Fc) were administered intraperitoneally once a week, immediately after the von Frey test at days 15, 22 and 29. PBS, rhLf or rhLf-Fc administration is indicated by Arrow mark. Response threshold is expressed as mean ± SE. Repeated one-way ANOVA was performed on data from day 0 to 13 that only OXL administration period. In the same way, repeated one-way ANOVA was done on data from 18 to 32 to evaluate the effects of drug (PBS, rhLf or rhLf-Fc) administration. #; P<0.05 vs. Glucose + PBS group. *; P<0.05 vs. OXL + PBS group.