Predictive efficacy comparisons of top 3 single-parameter models and top 3 multiple-parameter models between different glioma isocitrate dehydrogenase gene 1 (IDH1) status. Receiver-operating characteristic curve analysis showed the standard deviation of lesion standardized uptake value (SUVsd), total lesion tracer standardized uptake (TLU), and heterogeneity index (HI) had the top 3 single-parameter model performance in IDH1 status prediction; area under the curve (AUC) 0.710, 0.698, and 0.676, respectively. Combined model 1 was maximal tumor-to-background ratio (TBRmax), SUVsd, and mean tumor-to-background ratio; AUC was 0.821. Combined model 2 was the combination of SUVsd and TBRmean; AUC was 0.804. Combined model 3 was the combination of SUVsd, HI, and TBRmean; AUC was 0.799.