Fig. 5.

Favorable clinical outcome of LIHC patients with high expression of C15 signature genes. (a) Violin plots showing the expression of cluster-specific genes across the two fibroblast cell clusters (C15, C19) and three endothelial cell clusters (C8, C11, C18). Genes in each row were grouped into the cluster-specific gene set, i.e. G19, G15 and G11. (b) Kaplan-Meier curves showing the association between the cluster-specific gene set scores and patient survival time in TCGA LIHC cohorts. The score was defined by the sum expression of the signature genes in each gene set. The high or low groups were determined by the median of each score. Statistical significance comparing different groups was evaluated using the Log-rank test. (c) Boxplots showing G19, G11, G15 and G15-G11 scores across vascular invasion groups in TCGA LIHC cohort (None, Micro and Macro). Student's t-test was used to compare the differences in gene expression between vascular invasion groups (None, Micro and Macro). P-values were further adjusted with Benjamini and Hochberg method. *adjusted p<0.05, ***adjusted p<0.001.