Table 3.

Multivariate Regression Analyses Evaluating Predictors of Overall Graft Failure After Liver Transplantation.

						Pre-DAA				Post-DAA
		HR	95% CI		P	HR	95% CI		P	HR	95% CI		P
Gender	Male	1				1				1
	Female	0.95	0.93	0.98	0.0001	0.96	0.93	0.98	0.001	0.93	0.86	1.00	0.04
Ethnicity	White	1				1				1
	Black	1.18	1.14	1.22	<0.001	1.19	1.14	1.23	<0.001	1.17	1.05	1.30	0.005
	Hispanic	0.90	0.86	0.93	<0.001	0.89	0.85	0.92	<0.001	0.96	0.87	1.06	0.44
	Asian	0.76	0.72	0.81	<0.001	0.74	0.69	0.79	<0.001	0.91	0.77	1.09	0.31
HCV	No	1				1				1
	Yes	1.15	1.12	1.18	<0.001	1.18	1.15	1.21	<0.001	0.94	0.87	1.02	0.14
HCC	No	1				1				1
	Yes	1.09	1.06	1.13	<0.001	1.11	1.07	1.15	<0.001	1.03	0.94	1.13	0.46
Diabetes	No	1				1				1
	Yes	1.26	1.23	1.29	<0.001	1.27	1.24	1.31	<0.001	1.19	1.11	1.28	<0.001
Era	Pre-DAA	1
	Post-DAA	0.69	0.66	0.71	<0.001
Age at listing		1.01	1.01	1.01	<0.001	1.01	1.01	1.01	<0.001	1.01	1.00	1.01	0.002
BMI at transplant		0.99	0.99	0.99	<0.001	0.99	0.99	0.99	<0.001	0.99	0.99	1.00	0.02
Biologic MELD at transplant		1.01	1.01	1.01	<0.001	1.01	1.01	1.01	<0.001	1.01	1.01	1.02	<0.001

DAA = direct-acting antiviral; HR = hazard ratio; CI = confidence interval; BMI = body mass index; HCC = hepatocellular carcinoma; HCV = hepatitis C virus; UNOS = United Network for Organ Sharing.

Model adjusted for demographics, HCV status, HCC status, diabetes, treatment era, BMI, biologic MELD at transplant, age at listing, and UNOS region.