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. 2020 Dec 5;14(1):100975. doi: 10.1016/j.tranon.2020.100975

Fig. 3.

Fig 3

Cytochrome P4502E1 (CYP2E1) dependent ethanol metabolism induces FABP4 expression in vitro. (A) FABP4 mRNA expression in HepG2 and HuH7 cells and HepG2 and HuH7 stably transfected to express CYP2E1(E47 and HuH7-CYP) following exposure to vehicle (V; 0.1mL phosphate buffered saline) or 100 mM ethanol (EtOH; 48h). *P<0.05 EtOH versus V, transfected versus non-transfected, N = 4 independent experiments. FABP4 secretion into culture medium from (B) HepG2/E47 and (C) HuH7/HuH7-CYP cells following exposure to V or 50 mM EtOH (48h). *P<0.05 EtOH versus V transfected versus non-transfected, N = 4 independent experiments.