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. 2020 Dec 5;14(1):100975. doi: 10.1016/j.tranon.2020.100975

Fig. 4.

Fig. 4

rhFABP4 stimulates hepatoma cell proliferation and migration in vitro. (A) HepG2 and HuH7 cells were exposed to rhFABP4 (0–200 ng/mL, 48h) and assayed for cell proliferation. Negative and positive controls were 0.1% [v/v] and 10% [v/v] fetal bovine serum (FBS). *P<0.05 versus 0.1% [v/v] FBS, N = 4 independent experiments. (B) Representative images of HepG2 and HuH7 cell migration following 48h in the presence of 0.1% [v/v] FBS (control), 10% [v/v] FBS, 100 ng/mL or 200 ng/mL rhFABP4. (C) Cumulative analysis of HepG2 and HuH7 cell migration (crystal violet mean fluorescent intensity) following 48h in the presence of 0.1% [v/v] FBS (control), 10% [v/v] FBS, or rhFABP4 (5–200 ng/mL). *P<0.05 versus 0.1% [v/v] FBS and 5 ng/mL rhFABP4, N = 4 independent experiments.