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. 2020 Dec 6;14(1):100974. doi: 10.1016/j.tranon.2020.100974

Fig. 3.

Fig. 3

Schematic presentation of tsRNAs biogenesis. tsRNAs include tRF-1 s, tRF-2 s, tRF-3 s (type a,b), tRF-5 s (type a, b and c) and i-tRFs. tRF-1 s are the maturation products of tRNAs (not shown in figure). The anticodon loop of mature tRNAs can be cleaved by Angiogenin (ANG) to produce 3′tiRNAs and 5′tiRNAs. tRF-2 s are generated from the anticodon stem loop of tRNAs. tRF-3 s, which are derived from the 3′end of tRNAs, are generated by Dicer or ANG -dependent cleavage in the T loop. Similarly, tRF-5 s are derived from the 5′end of tRNAs in Dicer-dependent cleavage in the D loop. i-tRFs come mainly from the internal region of tRNA.