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| Tumor Stage | Recommendations | Comments |
|---|---|---|
| Nonmetastatic castration- resistant prostate cancer | Consider combination castration therapy with the new hormonal treatments (apalutamide, darolutamide, enzalutamide) in high selected patients. | These drugs have demonstrated benefits in terms of metastatic free survival in patients with PSA-DT < 10 months ( 1 , 15 , 16 ). |
PSA-DT = Prostate Specific Antigen - Doubling Time
