Fig. 9.

Abl kinase bound to imatinib adopts a ‘mixed’ conformation. The structures of Abl in the active state (left), the two inactive states (I₁ and I₂; middle), and the imatinib-bound state (right) are shown. The imatinib-bound state exhibits DFG and A-loop conformations resembling the I₂ inactive state, and αC and P-loop conformations resembling the active state [74]. The figure was adapted from Xie T, Saleh T, Rossi P, Kalodimos CG. Conformational states dynamically populated by a kinase determine its function. Science 2020;370:eabc2754. Reprinted with permission from AAAS.