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. 2020 Dec 7;13:170. doi: 10.1186/s13045-020-01013-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Overview of the clinical cohort and experimental workflow. a 16 types of treatment naïve primary human cancers (126 cancer samples, 94 tumor-matched normal adjacent tissues, and 12 normal tissues). Cancer abbreviation annotation: GBM (glioblastoma multiforme), HNSC (head and neck squamous cell carcinoma), LUAD (lung adenocarcinoma), LUSQ (lung squamous cell carcinoma), LUSC (lung small cell carcinoma), ESCA (esophagus squamous cell carcinoma), STAD (stomach adenocarcinoma), PAAD (pancreatic adenocarcinoma), COAD (colon adenocarcinoma), LIHC (liver hepatocellular carcinoma), KIRC (kidney renal clear cell carcinoma), BLCA (bladder urothelial carcinoma), PRAD (prostate adenocarcinoma), BRCA (breast invasive carcinoma), OV (ovarian high-grade serous carcinoma), and UCEC (uterine corpus endometrial carcinoma). b Experimental workflow for generating DIA-MS-based proteomic data. c The number of proteins identified in each cancer type