Table 4. Impact of steatosis on patients’ survival after liver transplantation.
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | OR (95% CI) | P value | ||
| Mixed steatosis (yes/noa) | 0.89 (0.28–2.88) | 0.85 | |||
| MiS (yes/noa) | 0.82 (0.38–1.78) | 0.62 | |||
| MaS (yes/noa) | 2.34 (1.23–4.48) | 0.01 | 2.14 (1.06–4.30) | 0.03 | |
| Age (years) | 1.03 (1.00–1.06) | 0.10 | 1.05 (1.01–1.09) | 0.01 | |
| Gender (F/M) | 0.98 (0.44–2.22) | 0.97 | |||
| Blood type (A/B/O/AB) | 1.17 (0.85–1.59) | 0.34 | |||
| BMI (kg/m2) | 1.01 (0.92–1.11) | 0.91 | |||
| AFP (ng/mL)/100 | 1.00 (0.98–1.03) | 0.79 | |||
| MELD score | 1.01 (0.97–1.05) | 0.72 | |||
| Operation time (hours) | 1.26 (0.98–1.63) | 0.08 | |||
| ALT (U/L)/1,000 | 1.33 (1.17–1.52) | <0.01 | 1.53 (1.11–2.12) | 0.01 | |
| AST (U/L)/1,000 | 1.10 (1.05–1.17) | <0.01 | |||
| TB (μmol/L)/100 | 1.20 (1.08–1.17) | <0.01 | 1.22 (1.07–1.40) | <0.01 | |
| PT (s) | 1.00 (0.99–1.33) | 0.76 | |||
| INR | 1.01 (1.00–1.02) | 0.16 | |||
| Blood loss (mL)/1,000 | 1.41 (1.22–1.64) | <0.01 | |||
| pRBC (U) | 1.05 (1.02–1.08) | <0.01 | |||
| FFP (mL)/1,000 | 1.94 (1.23–3.08) | 0.01 | |||
| PCC (U) | 1.15 (1.09–1.21) | <0.01 | 1.11 (1.03–1.20) | <0.01 | |
| Height (cm) | 1.01 (0.97–1.06) | 0.58 | |||
| Weight (kg) | 1.01 (0.98–1.04) | 0.63 | |||
| MiS degree | |||||
| MiS G1 (yes/noa) | 0.92 (0.31–2.78) | 0.89 | 1.01 (0.32–3.16) | 0.98 | |
| MiS G2 (yes/noa) | 1.29 (0.69–2.39) | 0.42 | 0.94 (0.48–1.85) | 0.86 | |
| MiS G3 (yes/noa) | 1.10 (0.56–2.16) | 0.78 | 1.16 (0.58–2.30) | 0.67 | |
| MaS degree | |||||
| MaS G1 (yes/noa) | 2.03 (0.79–5.19) | 0.14 | 1.89 (0.68–5.21) | 0.22 | |
| MaS G2 (yes/noa) | 2.05 (1.28–3.29) | <0.01 | 2.27 (1.21–4.25) | 0.01 | |
| MaS G3 (yes/noa) | 1.16 (0.71–1.89) | 0.55 | 1.34 (0.80–2.24) | 0.26 | |
Cox regression model was used for univariate and multivariate analysis. Factors significantly associated with patients’ survival (plus age) were enrolled into multi-covariate cox regression analysis. a, “no” represented the patients received allografts with absence of steatosis (non-steatosis group). G1/G2/G3 respectively represented the steatosis degree (0–10%], (10–20%), and [20%, upper limit]. AFP, alpha fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; F, female; INR, international normalized ratio; FFP, fresh frozen plasma; M, male; MaS, macrosteatosis; MELD, model for end-stage liver disease; MiS, microsteatosis; PCC, prothrombin complex concentrate; pRBC, packed red blood cells; PT, prothrombin time; TB, total bilirubin.