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. Author manuscript; available in PMC: 2021 Oct 21.
Published in final edited form as: J Am Chem Soc. 2020 Oct 8;142(42):17981–17988. doi: 10.1021/jacs.0c04388

Figure 3.

Figure 3.

Binding configuration of M-IV in MycG as observed in the cocrystal structure (PDB 2Y98; left), and binding configuration of the same substrate with C-14 constrained to be proximal to the heme iron of MycG (right). The FG (containing E173) and BC (containing R75 and E77) loops are shown and labeled accordingly. The I-helix (containing L227) adjacent to the heme group is also shown and labeled accordingly.