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. 2020 Nov 17;117(48):30639–30648. doi: 10.1073/pnas.2007935117

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — The up-regulated gene signature of CCR6⁺ cells in nonresponders but not responders is enriched in pathogenic Th17 cells. (A) The numbers of up-regulated and down-regulated DE genes in stimulated CCR6⁺ cells from nonresponder vs. healthy control comparison and responder vs. healthy control comparison (unpaired two-tailed Student’s t test, P < 0.05, FC ≥ 1.5) (nCounter). (B) Venn Diagram representations of the numbers of overlapped DE genes from the comparisons in A. (C) GSEA: enrichment of the up-regulated gene set of nonresponder vs. HC comparison in TGF-β3/IL-6 (Left) or IL-1/IL-6/IL-23 (Right) induced mouse pathogenic Th17 cells. (D) Venn diagram representations of leading-edge genes (enriched signature genes) in C: TGF-β3, genes enriched in TGF-β3/IL-6–induced Th17 cells; IL-1/6/23, genes enriched in the IL-1/IL-6/IL-23–induced Th17 cells. (NRes, nonresponder; Res, responder; HC, healthy donor; NES, normalized enrichment score).