Fig. 3.

B cell clones are shared between thymus and circulation before a thymectomy. A gDNA-based sequencing approach was used to confirm that B cells clones are shared between the thymus and circulation before thymectomy. The observed number of shared clones is shown for patient THY6 (A), patient THY7 (B), and patient THY2 (C). The computed background sharing is shown as Venn-diagrams for THY6 (D), patient THY7 (E), and patient THY2 (F). Background sharing was computed by changing the identity of the thymus used to assess for clonal sharing: That is, the observed sharing of clones from thymus samples derived from different patients with the circulation and computing an average. Uncertainty was computed as the SD of values from the corresponding background sharing and are shown in D–F using the “±” symbol.