Fig. 5.

Confirmation of B cell clonal sharing with the circulation in specimens (THY-Y) independent of the MGTX trial. (A) Observed number of clones shared between the prethymectomy, postthymectomy circulation, and thymus shown as Venn diagrams. (B) Computed background sharing between the prethymectomy, postthymectomy circulation and thymus are shown as Venn diagrams. Background sharing was computed by permuting the identity of the thymus used to assess for clonal sharing and computing an average; this approach is identical to the approach used to compute clonal sharing for thymus samples from the MGTX trial. Uncertainty was computed as the SD of the background clonal sharing and shown using the “±” symbol. Statistical testing of observed counts of shared clones between circulation and thymus repertoire (C) prethymectomy and (D) postthymectomy. Statistical differences are shown only when significant (****P < 0.0001).