Table 4.
The frequency of all grade toxicities in patients with DPYD wild type and mutants
| DPYD wild type (n = 48) | DPYD mutant (n = 56) | |||||
|---|---|---|---|---|---|---|
| DPYD*5A (n = 40*) | DPYD*9A (n = 25*) | |||||
| Toxicities | G 1–2 | G 3–4 | G 1–2 | G 3–4 | G 1–2 | G 3–4 |
| Hematological toxicity | ||||||
| Anemia | 22(21.2) | 9(8.7) | 17(16.3) | 8(7.7) | 12(11.5) | 4(3.8) |
| Leucopenia | 21(20.2) | 4(3.8) | 20(19.2) | 4(3.8) | 11(10.6) | 3(2.9) |
| Neutropenia | 17(16.3) | 5(4.8) | 17(16.3)) | 8(7.7) | 8(7.7) | 6(5.8) |
| Thrombocytopenia | 16(15.4) | 4(3.8) | 16(15.4) | 6(5.8) | 12(11.5) | 4(3.8) |
| Gastrointestinal toxicity | ||||||
| Mucositis | 2(1.9) | 7(6.7) | 2(1.9) | 2(1.9) | 0(0) | 0(0) |
| Vomiting | 12(11.5) | 13(12.5) | 13(12.5) | 7(6.7) | 5(4.8) | 4(3.8) |
| Diarrhea | 7(6.7) | 7(6.7) | 5(4.8) | 2(1.9) | 1 (0.9) | 1(0.9) |
| Dermatology toxicity | ||||||
| Skin ulceration | 1(0.9) | 1(0.9) | 4(3.8) | 3(2.9) | 0(0) | 0(0) |
| Hand-foot skin reaction | 4(3.8) | 1(0.9) | 6(5.8) | 4(3.8) | 1(0.9) | 0(0) |
Data are presented as n (%)
*9 patients had double heterozygous status for DPYD*5A and DPYD*9A variants