Table 6.
Association between polymorphisms of DPYD and GSTP1 genes and hematological toxicity of chemotherapy
| Genotype | Anemia | Neutropenia | Thrombocytopenia | Leucopenia | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Grade 1–2 | Grade 3–4 | P | Grade 1–2 | Grade 3–4 | P | Grade 1–2 | Grade 3–4 | P | Grade 1–2 | Grade 3–4 | P | ||
| DPYD*5A (c.1627A > G) | WT | 29 | 11 | Ref. | 22 | 8 | Ref. | 23 | 6 | Ref. | 28 | 6 | Ref. |
| HET | 16 | 7 | 0.804 | 14 | 7 | 0.607 | 14 | 5 | 0.650 | 17 | 4 | 0.896 | |
| HOM | 1 | 1 | 0.492 | 3 | 1 | 0.943 | 2 | 1 | 0.614 | 3 | 0 | 0.427 | |
| HET + HOM | 17 | 8 | 0.698 | 17 | 8 | 0.665 | 16 | 6 | 0.583 | 20 | 4 | 0.922 | |
| DPYD*9A (c.85T>C) | WT | 34 | 15 | Ref. | 31 | 10 | Ref. | 27 | 8 | Ref. | 37 | 7 | Ref. |
| HET | 12 | 4 | 0.668 | 8 | 6 | 0.189 | 12 | 4 | 0.867 | 11 | 3 | 0.794 | |
| HOM | 0 | 0 | – | 0 | 0 | – | 0 | 0 | – | 0 | 0 | – | |
| HET + HOM | 12 | 4 | 0.668 | 8 | 6 | 0.189 | 12 | 4 | 0.867 | 11 | 3 | 0.794 | |
| GSTP1 (c.313A>G) | WT | 31 | 14 | Ref. | 30 | 13 | Ref. | 26 | 8 | Ref. | 35 | 7 | Ref. |
| HET | 14 | 4 | 0.480 | 9 | 3 | 0.724 | 11 | 3 | 0.875 | 11 | 2 | 0.913 | |
| HOM | 1 | 1 | 0.575 | 0 | 0 | – | 1 | 1 | 0.401 | 2 | 1 | 0.466 | |
| HET + HOM | 15 | 5 | 0.617 | 9 | 3 | 0.724 | 12 | 4 | 0.910 | 13 | 3 | 0.851 | |