Table 7.
Association between polymorphisms of DPYD and GSTP1 genes and gastrointestinal toxicity of chemotherapy
| Genotype | Mucositis | Vomiting | Diarrhea | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Grade 1–2 | Grade 3–4 | P | Grade 1–2 | Grade 3–4 | P | Grade 1–2 | Grade 3–4 | P | ||
| DPYD*5A (c.1627A>G) | WT | 2 | 7 | Ref. | 14 | 16 | Ref. | 7 | 7 | Ref. |
| HET | 1 | 2 | 0.700 | 12 | 5 | 0.113 | 4 | 2 | 0.052 | |
| HOM | 1 | 0 | 0.107 | 2 | 2 | 0.900 | 1 | 0 | 0.533 | |
| HET + HOM | 2 | 2 | 0.317 | 14 | 7 | 0.158 | 5 | 2 | 0.107 | |
| DPYD*9A (c.85T>C) | WT | 4 | 9 | Ref. | 23 | 19 | Ref. | 11 | 8 | Ref. |
| HET | 0 | 0 | – | 5 | 4 | 0.965 | 1 | 1 | 0.830 | |
| HOM | 0 | 0 | – | 0 | 0 | – | 0 | 0 | – | |
| HET + HOM | 0 | 0 | – | 5 | 4 | 0.965 | 1 | 1 | 0.830 | |
| GSTP1 (c.313A>G) | WT | 2 | 7 | Ref. | 22 | 12 | Ref. | 8 | 7 | Ref. |
| HET | 2 | 2 | 0.317 | 5 | 10 | 0.042 | 4 | 2 | 0.577 | |
| HOM | 0 | 1 | 0.598 | 0 | 1 | 0.187 | 0 | 0 | – | |
| HET + HOM | 2 | 3 | 0.480 | 5 | 11 | 0.027 | 4 | 2 | 0.577 | |