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. 2020 Dec 6;18:321. doi: 10.1186/s12957-020-02103-3

Table 8.

Association between polymorphisms of DPYD and GSTP1 genes and dermatology toxicity of chemotherapy

Genotype Skin ulceration Hand-foot skin reaction
Grade 1–2 Grade 3–4 P Grade 1–2 Grade 3–4 P
DPYD*5A (c.1627A>G) WT 2 1 Ref. 5 1 Ref.
HET 2 1 1.000 4 3 0.308
HOM 2 2 0.659 2 1 0.571
HET + HOM 4 3 0.778 6 4 0330
DPYD*9A (c.85T>C) WT 6 4 Ref. 10 5 Ref.
HET 0 0 1 0 0.486
HOM 0 0 0 0
HET + HOM 0 0 1 0 0.486
GSTP1 (c.313A>G) WT 5 1 Ref. 8 2 Ref.
HET 0 3 0.018 3 3 0.210
HOM 0 0 0 0
HET + HOM 0 3 0.018 3 3 0.210