Table 8.
Clinicopathological findings of GI-NEN cases in which MGMT promoter methylation status was analyzed using methylation-specific PCR
| Case No.a | Primary site | Grade | Ki-67 labeling index | MGMT score | H-score | MGMT methylation-specific PCR |
|---|---|---|---|---|---|---|
| 1 | rectum | NET G2 | 6.83572 | 1 | 3.65854 | negative |
| 2 | stomach | NET G2 | 10.9264 | 2 | 182.374 | negative |
| 3 | rectum | NET G2 | 3.73832 | 3 | 271.554 | negative |
| 4 | rectum | NET G1 | 1.17057 | 3 | 257.354 | negative |
| 5 | rectum | NET G1 | 1.38648 | 3 | 207.671 | negative |
| 6 | duodenum | NET G1 | 0.874317 | 3 | 232.395 | negative |
| 7 | rectum | NET G1 | 0.334076 | 3 | 175.391 | negative |
| 8 | duodenum | NET G2 | 5.42636 | 3 | 291.156 | negative |
| 9 | rectum | NET G1 | 0.475436 | 3 | 246.119 | negative |
| 10 | duodenum | NET G2 | 3.52588 | 3 | 176.573 | negative |
| 11 | duodenum | NET G1 | 2 | 3 | 240.253 | negative |
| 12 | duodenum | NET G1 | 1.97239 | 3 | 275.166 | negative |
| 13 | rectum | NET G1 | 1.33038 | 3 | 298.588 | negative |
| 14 | rectum | NET G1 | 0.740741 | 3 | 270.837 | negative |
| 15 | rectum | NET G1 | 1.37741 | 3 | 243.583 | negative |
| 16 | rectum | NET G2 | 11.9792 | 3 | 204.144 | negative |
| 17 | duodenum | NET G1 | 2.89389 | 2 | 111.254 | negative |
| 18 | rectum | NET G1 | 0.788955 | 3 | 243.867 | negative |
| 19 | duodenum | NET G2 | 12.8111 | 2 | 282.641 | negative |
| 20 | rectum | NET G1 | 1.44778 | 3 | 298.456 | negative |
| 21 | duodenum | NET G1 | 1.0043 | 3 | 227.732 | negative |
| 22 | rectum | NET G2 | 3.78007 | 3 | 288.949 | negative |
| 23 | rectum | NET G1 | 0.797101 | 3 | 248.495 | negative |
| 24 | stomach | NET G2 | 3.10786 | 3 | 260.254 | negative |
| 25 | rectum | NET G1 | 2.23842 | 3 | 254.59 | negative |
| 26 | rectum | NET G1 | 1.46036 | 3 | 268.528 | negative |
| 27 | rectum | NET G1 | 1.27907 | 3 | 232.112 | negative |
| 28 | stomach | NET G1 | 1.86757 | 3 | 217.736 | negative |
| 29 | stomach | NET G2 | 3.7929 | 1 | 67.3792 | negative |
| 30 | stomach | NET G1 | 1.60494 | 3 | 296.608 | negative |
| 31 | rectum | NET G1 | 2.55924 | 2 | 191.369 | negative |
| 32 | rectum | NET G1 | 0.840925 | 3 | 257.453 | negative |
| 33 | duodenum | NET G1 | 1.90476 | 2 | 117.661 | negative |
| 34 | rectum | NET G2 | 7.36722 | 2 | 141.194 | negative |
| 35 | duodenum | NET G1 | 0.623539 | 1 | 158.554 | negative |
| 36 | EG junction | NEC | 96.223 | 3 | 223.134 | negative |
| 37 | stomach | NEC | 99.1404 | 2 | 193.032 | negative |
| 38 | sigmoid colon | NEC | 92.9985 | 0 | 0 | positive |
| 39 | esophagus | NEC | 74.7155 | 3 | 217.818 | negative |
| 40 | stomach | NEC | 99.7234 | 3 | 246.952 | negative |
| 41 | esophagus | NEC | 100 | 3 | 243.81 | negative |
| 42 | stomach | NEC | 77.2152 | 2 | 205.957 | negative |
| 43 | stomach | NEC | 85.7143 | 3 | 250.857 | negative |
| 44 | stomach | NEC | 79.533 | 2 | 166.723 | negative |
| 45 | esophagus | NEC | 99.2844 | 3 | 119.098 | negative |
| 46 | rectum | NEC | 95.1153 | 3 | 146.898 | negative |
| 47 | rectum | NEC | 88.974 | 2 | 212.279 | negative |
| 48 | sigmoid colon | NEC | 98.7198 | 3 | 155.372 | positive |
| 49 | duodenum | NEC | 98.7441 | 3 | 225.577 | negative |
aPatient characteristics of these cases: male, n = 32; female, n = 17/ Median age in years (range), 66 (39–86)