Figure 4: Predictive value of RP805 imaging.

A, Examples of RP805 micro-SPECT/CT images at 1 week in an angiotensin II–infused mouse that did not (left) and a mouse that did (right) develop aneurysm at 4 weeks. Top row, transverse CT angiographic images and bottom row, transverse fused micro-SPECT and CT angiographic images. Arrows indicate suprarenal abdominal aorta. B, Quantification of micro–SPECT/CT-derived suprarenal aorta RP805 uptake in images obtained at 1 week in mice that developed abdominal aortic aneurysm (AAA) or died of AAA rupture by 4 weeks after starting angiotensin II infusion and those that did not develop AAA, *P=0.001. C, Correlation between RP805 in suprarenal abdominal aorta at 1 week and aortic diameter at 4 weeks after angiotensin II infusion. Dotted lines represent 95% confidence interval for the linear regression line. AU indicates arbitrary unit; cpv, counts per voxel; and MMP, matrix metalloproteinase. Reprinted from Golestani et al²⁵ with permission of the publisher. Copyright @ 2015, Springer.