Table 1.

RNA modifying proteins of m6A in gastrointestinal cancers

Cancer types	RMPs	Expression	Biological FUNCTIONS	Targets	References
Gastric cancer (GC)	METTL3	Up	Promote GC cell proliferation and liver metastasis	HDGF mRNA	[86]
			Facilitate the EMT program and matastasis	ZMYM1 mRNA	[87, 88]
	ALKBH5	Up	Promote GC cell invasion and migration	NEAT1	[89]
Colorectal cancer (CRC)	METTL3	Up	Promote CRC cell self-renewal and colorectal tumor growth and metastasis	SOX2 mRNA	[91]
			Promote CRC metastasis	pri-miR-1246	[91]
		Down	Inhibit CRC cell proliferation, invasion and migration	Unknown	[92]
			Inhibit CRC cell growth and invasion, tumor growth and metastasis	SOX4 mRNA	[94]
			Inhibit CRC cell proliferation and invasion, tumorigenicity and metastasis	XIST mRNA	[95]
	YTHDF1	Up	Promote CRC cell proliferation, drug sensitivity and tumor growth	Unknown	[96, 97]
Liver cancer (HCC)	METTL3	Up	Promote HCC cell proliferation, tumorigenicity and lung metastasis	SOCS2 mRNA	[68]
	METTL14	Down	Inhibit tumor metastasis	microRNA 126	[68, 98]
				DGCR8 mRNA	[99]
	WTAP	Up	Enhance HCC cell proliferation and tumor progression	ETS1 mRNA	[99]
	KIAA1429	Up	Promote the proliferation and invasion of HCC cells	ID2 mRNA	[100]
	FTO	Up	Promote the proliferation and tumor growth	PKM2 mRNA	[101]
		Down	Increase the apoptosis of ICC cells and reduce resistance to cisplatin treatment	Unknown	[102]
	YTHDF2	Down	Enhance inflammation, vascular reconstruction and metastatic progression of HCC cells	IL-11, SERPINE2 mRNA	[103]
Pancreatic cancer (PC)	METTL3	Up	Promote PC cell proliferation and invasion	Unknown	[105, 106]
	ALKBH5	Down	Inhibit PC cell motility	KCNK15-AS1	[107]
			Inhibit PDAC cell proliferation, migration, and invasion both in vitro and in vivo	WIF-1mRNA	[108]