Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 7;13:169. doi: 10.1186/s13045-020-01009-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 6 — Inhibition of the FAK signalling pathway increases sensitivity to EGFR-TKIs in PC9 cells. a The sensitivity of PC9GR cells treated with VS-6063 to gefitinib was determined by CCK-8 assays. b The effect of gefitinib combined with VS-6063 treatment on the proliferation of PC9GR cells. c Fluorescence-activated cell sorting (FACS) analysis was performed to investigate the effects of gefitinib combined with VS-6063 treatment on apoptosis in PC9GR cells. d Western blot analysis was used to detect the effect of gefitinib combined with VS-6063 treatment on CyclinD1 and PARP in PC9GR cells. e Under gefitinib treatment, p-FAK, p-AKT and p-ERK levels in PC9 cells transfected with si-FAK or si-NC were detected by western blot analysis (**P < 0.01; ***P < 0.001)