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. 2020 Dec 7;8:212. doi: 10.1186/s40478-020-01075-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Overexpression of CLAC-P altered the morphology of Aβ deposits (J20 line). a–h Immunohistochemical analyses of the brains of 6- (a and e), 9- (b and f), 12- (c and g) and 15- (d and h) month-old APP tg mice (J20 line, a–d) and double tg mice (e–h) using an anti-human Aβ antibody (82E1). High magnification images (insets in d and h) were shown in i and j, respectively. Diffuse amyloid plaques (c and d, arrowheads) and huge plaques (i) were shown in the hippocampi of APP tg mice. On the other hand, numerous middle-sized plaques were predominant in the hippocampi of 12- and 15-month-old double tg mice (g, h and j, arrows). Scale bar shows 200 μm (a–h) and 50 μm (i and j). k Quantitative analysis of the amyloid burden (%Aβ immunoreactive areas) in the hippocampus of APP and double tg mice. N = 4, 4, 13, 7 for 6-, 9-, 12-, 15-month-old APP tg, respectively. N = 6, 3, 11, 7 for 6-, 9-, 12-, 15-month-old double tg, respectively. Mann–Whitney U test, p = 0.29 (6-month-old), 0.48 (9-month-old), 0.019 (12-month-old), 0.018 (15-month-old). l Quantitative analysis of the amyloid burden at the molecular layer of hippocampal dentate gyrus of 15-month-old APP and double tg mice. N = 6 (APP tg) and 7 (double tg). Student’s t-test, p = 0.024, *, p < 0.05 (m, n) Average circularity (m) and size (n) of Aβ plaques in the hippocampus of 15-month-old APP and double tg mice. Note that Circularity value of 1.0 indicates a perfect circle. N = 6 (APP tg) and 7 (double tg). Student’s t-test, p = 0.0076, **, p < 0.01 (n) N = 6 (APP tg) and 7 (double tg). Student’s t-test, p = 0.76