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. 2020 Dec 7;8:212. doi: 10.1186/s40478-020-01075-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Endogenous and overproduced CLAC co-deposited with Aβ on the Aβ deposits. a–f Immunohistochemical analyses of the brains of 12-month-old APP tg (J20 line, a and b) and double tg mice (c–f) by anti-human Aβ (BAN50) (a, c and e) and anti-CLAC antibodies (anti-NC4) (b, d and f). High magnification images (insets in c and d) are shown in (e) and (f), respectively. In hippocampus of APP tg mice, immunoreactivities of murine endogenous CLAC were positive in a part of Aβ plaques (arrows in a and b). Middle-sized plaques in the hippocampus of double tg mice were visualized by anti-Aβ and anti-CLAC antibodies (arrows in c–f). Scale bar shows 200 μm (a–d) and 100 μm (e and f)