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. 2020 Dec 7;8:212. doi: 10.1186/s40478-020-01075-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Overexpression of CLAC-P significantly increased the number of ThS-positive plaques. a, b ThS staining of the brains of 15-month-old APP tg (J20 line, a) and double tg mice (b). c The mean number of ThS-positive plaques was assessed in the hippocampus of 6-, 9-, 12- and 15-month-old APP tg mice (blue circles) and double tg mice (red triangles). N = 4, 4, 13, 7 for 6-, 9-, 12-, 15-month-old APP tg, respectively. N = 4, 3, 12, 7 for 6-, 9-, 12-, 15-month-old double tg, respectively. Student’s t-test, p = 0.81 (6-month-old), p = 0.24 (9-month-old), p < 0.0001 (12-month-old), p < 0.0001 (15-month-old). d, e Serial sections stained with ThS (d) and anti-Aβ antibody (BAN50) (e) were shown. The core-region of middle-sized plaques in the brains of 15-month-old double tg mice were exclusively labeled by ThS (arrows). f, g ThS staining of the brains of 18-month-old APP tg (f) and double tg (g) mice. h The mean number of ThS-positive plaques assessed in the parietal, piriform and frontal cortices of APP tg and double tg mice. N = 4, Student’s t-test, p = 0.86 (parietal cortex), 0.070 (piriform cortex), 0.00063 (frontal cortex), **, p < 0.01. Scale bar shows 200 μm (a and b), 50 μm (d and e), 100 μm (f and g)