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. 2020 Dec 7;8:212. doi: 10.1186/s40478-020-01075-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Overexpression of CLAC-P significantly increased the number of ubiquitin-positive neuritic plaques. a–d Immunohistochemical analyses of the brains of 15-month-old APP tg mice (J20 line, a and c) and double tg mice (b and d) using an anti-human Aβ antibody (BAN50) (a and b) and an anti-ubiquitin antibody (c and d). High magnification images (insets in b and d) were shown in e and f, respectively. A part of both Aβ and ubiquitin positive plaques were highlighted (arrows). Scale bar shows 200 μm (a–d) and 50 μm (e and f). g The mean number of ubiquitin-positive plaques was assessed in the hippocampus of 15-month-old APP tg mice (blue, N = 6) and double tg mice (red, N = 7). Mann–Whitney U test, p = 0.0066