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. 2020 Dec 7;8:212. doi: 10.1186/s40478-020-01075-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — ISF Aβ in the brain of double tg was significantly decreased compared with APP tg. a The concentration of Aβ42 (pmol/g wet tissue) in the TBS-soluble fraction of the brains of 18–19-month-old APP tg (A7 line) and double tg mice. N = 13 (APP tg), and 9 (double tg). The mean ± SD Student’s t-test, p = 0.31 n.s. means no significant difference. b Correlation between the concentration of TBS-soluble Aβ42 and area of Aβ deposits in hippocamps of the brains of 18–22-month-old APP and double tg mice. R² = 0.322 (APP tg), R² = 0.108 (double tg). c The concentration of Aβ42 (pM) in brain ISF of 18–19-month-old APP and double tg mice. N = 13 (APP tg), and 12 (double tg). The mean ± SD Student’s t-test, p = 0.040. d Correlation between the concentration of ISF Aβ42 and area of Aβ deposits in hippocamps of the brains of 18–22-month-old APP and double tg mice. R² = 0.385 (APP tg), R² = 0.0416 (double tg). e The concentration of Aβ42 (pmol/g wet tissue) in the TBS-soluble fraction of the brains of 5–7-month-old APP and double tg mice. N = 4 (APP tg), and 4 (double tg). The mean ± SD Welch’s t-test, p = 0.67. n.s. means no significant difference. f The concentration of ISF Aβ42 (pM) in the brains of 5–7-month-old APP and double tg mice. N = 4 (APP tg), and 4 (double tg). The mean ± SD Student’s t-test, p = 0.28. n.s. means no significant difference