Table 3.
The DLNM estimates of the cumulative association
| Exposure window | All newborns | Boys | Girls | |
|---|---|---|---|---|
|
IGF2 Factor1 |
Overall | 0.11 (− 0.71, 0.94) | − 0.25 (− 1.15, 0.64) | 0.35 (− 1.11, 1.81) |
| Trimester 1 | 0.07 (− 0.57, 0.71) | 0.25 (− 0.52, 1.01) | 0.44 (− 0.79, 1.67) | |
| Trimester 2 | − 0.02 (− 0.49, 0.45) | − 0.27 (− 0.79, 0.24) | 0.04 (− 0.81, 0.89) | |
| Trimester 3 | 0.06 (− 0.30, 0.41) | − 0.23 (− 0.68, 0.21) | − 0.13 (− 0.73, 0.48) | |
|
IGF2 Factor5 |
Overall | − 0.14 (− 1.11, 0.83) | 0.06 (− 1.52, 1.64) | − 0.40 (− 1.83, 1.02) |
| Trimester 1 | 0.02 (− 0.77, 0.81) | 0.25 (− 1.10, 1.60) | − 0.55 (− 1.75, 0.65) | |
| Trimester 2 | 0.03 (− 0.55, 0.61) | − 0.06 (− 1.02, 0.90) | 0.24 (− 0.60, 1.09) | |
| Trimester 3 | − 0.19 (− 0.61, 0.24) | −0.13 (− 0.93, 0.67) | −0.09 (− 0.69, 0.51) | |
|
H19 Factor2 |
Overall | −0.54 (− 1.29, 0.20) | −0.29 (− 1.47, 0.89) | −0.34 (− 1.42, 0.74) |
| Trimester 1 | 0.07 (−0.54, 0.68) | − 0.15 (− 1.15, 0.86) | 0.46 (− 0.45, 1.37) | |
| Trimester 2 | −0.16 (− 0.60, 0.29) | −0.08 (− 0.80, 0.64) | −0.07 (− 0.73, 0.59) | |
| Trimester 3 | −0.46 (− 0.79, − 0.13) | −0.06 (− 0.71, 0.58) | −0.73 (− 1.20, − 0.26) | |
|
H19 Factor5 |
Overall | 0.61 (−1.19, 1.42) | 0.87 (− 0.53, 2.27) | 0.23 (− 1.02, 1.48) |
| Trimester 1 | 0.70 (0.05, 1.35) | 0.71 (−0.48, 1.90) | 0.56 (− 0.49, 1.61) | |
| Trimester 2 | −0.11 (− 0.58, 0.36) | −0.07 (− 0.92, 0.78) | −0.22 (− 0.98, 0.54) | |
| Trimester 3 | 0.02 (−0.33, 0.37) | 0.23 (− 0.47, 0.94) | −0.11 (− 0.66, 0.43) |
The cumulative effect of a 5 μg/m3 increase in PM2.5 concentration on IGF2 Factor1 and Factor5 and H19 Factor2 and Factor5 over different exposure windows. Estimated in all observations (n = 189), in boys (n = 98) and in girls (n = 91), respectively. Confidence intervals are shown with lower and upper bounds. Confidence level for IGF2 factors in all-observation analysis is 99.36% and that of sex-specific analysis is 99.68%. Confidence level for H19 factors in all-observation analysis is 99.15% and that of sex-specific analysis is 99.57%