Fig. 3.

Three mutation categories and mutation analysis. (a) Consequences of somatic mutations on encoded peptide sequences are categorized and relative proportions are shown across three regional mutation categories (common, primary-specific, and CTC-specific). (b) Similarly shown for six mutation spectra. (c) Mutation signature levels estimated across mutation categories are shown in a heatmap with a dendrogram. Two arrows indicate signatures of 2 and 13. (d). Mutation allele frequencies of mutations are shown as clonality measures