FIGURE 4.
Effect of BI 1265162 on a) retention of tracer in lung of sheep and b) K+ concentration in sheep; n=2 per dose. Adult ewes were administered varying doses of BI 1265162 or vehicle using an AirLife™ nebuliser. Mucociliary clearance was measured by administration of aerosolised technetium-labelled sulfur colloid followed by γ scintigraphy. Serial images were obtained over a 2-h period, and counts were obtained from the right lung. Blood was collected and plasma potassium was determined to assess renal effects of BI 1265162. Data are presented as mean (range). #p=0.0027 and 0.0003 at 2 h after radiolabel administration, vehicle versus 1 μg·kg−1 and 10 μg·kg−1, respectively; one-way ANOVA.