Table 2. Effect of the thixogel formulation upon the Minimum Inhibitory Concentrations (MIC) of antibiotics against the main two bacterial pathogens associated with otitis externa.
Actual doses of ciprofloxacin (3000 μg/mL) and imipenem (10,000 μg/mL) used in ear and eye drop applications are over three orders of magnitude greater than the MIC concentrations. The MIC concentration inhibits 99.9% of bacterial growth.
| Minimum Inhibitory Concentrations (MIC) (μg/mL) | ||||||
|---|---|---|---|---|---|---|
| S. aureus 13709 | P. aeruginosa 27853 | |||||
| No Gel | S-Tx | H-Tx | No Gel | S-Tx | H-Tx | |
| Vancomycin | 2 | 4 | 16 | > 4 | > 32 | > 32 |
| Ciprofloxacin | 0.25 | 0.125 | 0.125 | 0.25 | 0.25 | 0.125 |
| Imipenem | 0.032 | 0.125 | < 0.032 | 2 | > 4 | 4 |
| Gentamycin | 1 | 8 | 32 | 2 | 32 | 32 |