Figure 6. (A) MTS assay verified that MCF-7/TR cell line (IC50 17.21μM) was less sensitive to tamoxifen than MCF-7 cell line (IC50 7.46 μM) (P < 0.05). (B) RT–qPCR experiments confirmed that small interfering RNA (siRNA) resulted in over 60% reduction in expression of 10 hub genes. (C) MTS assay showed that knockdown of HSPH1 may lead to reduced growth of MCF-7/TR cell with a trend close to significance (P = 0.07), whereas knockdown of other genes did not significantly affect cell growth.
