Table 2. The effect of clinical, pathologic, and genetic features on CPI response in Merkel cell carcinoma patients (multivariate logistic regression modeling).
| Variable | Total (n = 39) | ||
|---|---|---|---|
| OR | [95% CI] | p-value | |
| Female sex | 3.00 | 0.05–163.94 | 0.59 |
| Older age at diagnosis | 0.91 | 0.78–1.06 | 0.24 |
| Higher stage at diagnosis | 0.06 | < 0.01–0.92 | 0.04 |
| Smoking history (current or former) | 0.71 | 0.03–14.63 | 0.83 |
| Immunosuppressed | 0.05 | < 0.01–2.87 | 0.15 |
| Longer time to recurrence | 0.75 | 0.56–0.99 | 0.05 |
| Greater CPI line of therapy | 1.21 | 0.35–4.24 | 0.76 |
| Higher absolute lymphocyte count | 1.12 | 0.69–1.82 | 0.64 |
| Grade 3 or greater adverse eventsA | 12.39 | 0.67–229.27 | 0.09 |
| Higher total mutational burden | 0.94 | 0.83–1.07 | 0.35 |
| MCCP | 0.28 | 0.01–13.39 | 0.52 |
Female sex, smoking history, immunosuppressed, grade 3 or greater adverse events, and MCCP are binary categorical variables. Stage at diagnosis and line of therapy are ordinal categorical variables. All other variables are continuous variables. Bolded p-values represent those below 0.05. Only includes patients evaluable for radiographic response. CI = confidence interval; CPI = immune checkpoint inhibitor; MCCP = Merkel cell carcinoma polyomavirus positive; OR = Odds ratio (response vs. non-response). AUsing Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.