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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Toxicol Sci. 2020 Jan 1;173(1):202–225. doi: 10.1093/toxsci/kfz201

Figure 7. Further understanding of the POD ratio distribution.

Figure 7.

(A) The log10POD ratio is illustrated for the PODNAM,95 and the PODNAM, 50. The solid black line indicates where the log10-POD ratio95 is 0. Using the more conservative (i.e., lower) PODNAM,95, 48 of the 448 substances (10.7%) demonstrated a log10POD ratio < 0 (to the left of the dashed vertical line), whereas 92 of the 448 substances (20.5%) demonstrated a log10-POD ratio < 0 using the PODNAM,50. The medians of the log10-POD ratio distributions are indicated by dashed lines for PODNAM, 95 and PODNAM, 50 as 2 and 1.2, respectively. (B) Maximum AED (max AED) was less than the PODtraditional (5th-%ile POD) in 60% of the cases where the log10POD ratio95 > 0 (using PODNAM, 95). For the 48 chemicals with log10POD ratio95 < 0, the max AED was within the range of PODtraditional.