Figure 4.

Grade 3+ CTCAE adverse event rate in patients who received HER2-targeted therapy. Proportions for grade 3+ CTCAE adverse event rate were extracted from eligible studies and pooled in a meta-analysis. Studies here are stratified by study design. The size of each box represents the weight of each study in the meta-analysis. The vertical dashed and dotted lines represent the points of summary for fixed and random effects models, respectively, and the diamonds represent 95% CI. Analyses were performed with the R programming language³⁰ and the R package meta.³²