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(A) CryoEM structure of the KATP channel viewed from the side (left) and the top (right). (B) Left: SUR1 topology showing the different domains. Right: Structure of SUR1 built from cryoEM density map showing the glibenclamide (GBC) binding site above NBD1 in the transmembrane bundle formed by transmembrane helices from both TMD1 and TMD2.
