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. 2020 Dec 10;77(1):147–157. doi: 10.1161/HYPERTENSIONAHA.120.16002

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© 2020 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Hemodynamic, neural and autonomic changes to Ang II. A, Mean arterial pressure (MAP) and heart rate (HR) measured by telemetry throughout the experiment in intracerebroventricular (ICV), saline (n=6), and Ang II (angiotensin II; n=7) infused rats. B, Representative digital images of FosB (Proto-Oncogene) staining in saline- and Ang II-infused rats. Each pair of saline- and Ang II-infused images were adjusted for uniform brightness and contrast; scale bar=100 μm, (C) the mean number of FosB-positive cells in the paraventricular nucleus of the hypothalamus. n=3–4/group. D, Cardiac sympathetic tone and (E) cardiac parasympathetic tone calculated by the changes in HR responses to methylatropine and propranolol, and (F) the ratio between these variables in the Saline (n=6) and Ang II (n=7) infused rats. T-test (with Welch correction; A, C, D, E, and F). **P=0.004, *P=0.048 (A); ***P=0.0007 (C); *P=0.021 (D); *P<0.042 (E); *P=0.042 (F) vs saline control.