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. 2020 Nov 23;58(1):70–82. doi: 10.3892/ijo.2020.5151

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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W922 negatively regulates the cell cycle processes. (A) Volcano plot for protein abundances in HCT116 cells after W922 treatment. Red and green color points indicate significant up (FC >2)- and downregulated (FC <0.5) proteins, respectively. The lines represent P-values of 0.01 and 0.05 in two-tailed unpaired t-test. (B) Venn plot for proteins (P<0.05) in HCT116 cells after W922 treatment. (C) Heatmap of top 30 up (right)- and downregulated (left) proteins in W922 treatment. (D) Gene Ontology term enrichment of all significant downregulated proteins (FC <0.5; P<0.05) in W922 treated HCT116 cells. (E) Gene Ontology term enrichment of all significant upregulated proteins (FC >2; P<0.05) in W922 treated HCT116 cells. (n=3-5, unpaired Student's t-test). FC, fold change; Ctrl, control; BP, Biological process; MF, molecular function; CC, Cellular component; NR, negative regulation.