Table 1.
Relationship between different drug-resistant genes and clinicopathological variables of breast cancers
| Total | Topo II |
P | LRP |
P | GST-π |
P | P-gp |
P | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| − (%) | + (%) | − (%) | + (%) | − (%) | + (%) | − (%) | + (%) | ||||||
| Histological grade | 0.001* | 0.78 | 0.45 | 0.08 | |||||||||
| I | 16 | 14 (87.5) | 2 (12.5) | 8 (50.0) | 8 (50.0) | 6 (37.5) | 10 (62.5) | 8 (50.0) | 8 (50.0) | ||||
| II | 336 | 150 (44.6) | 186 (55.4) | 176 (52.3) | 160 (47.6) | 162 (48.2) | 174 (51.8) | 149 (44.3) | 187 (55.7) | ||||
| III | 196 | 81 (41.3) | 115 (58.7) | 90 (45.9) | 106 (54.1) | 86 (43.9) | 110 (56.1) | 68 (34.7) | 128 (65.3) | ||||
| Vessel thrombus | 0.89 | 0.17 | 0.47 | 0.43 | |||||||||
| Negative | 500 | 211 (42.2) | 289 (57.8) | 246 (49.2) | 244 (48.8) | 242 (48.4) | 258 (51.6) | 202 (40.4%) | 298 (59.6%) | ||||
| Positive | 48 | 34 (70.8) | 14 (29.2) | 28 (58.3) | 20 (42.7) | 22 (45.8) | 26 (54.2) | 23 (47.9%) | 25 (52.1%) | ||||
| Clinical stage | 0.73 | 0.14 | 0.62 | 0.90 | |||||||||
| I | 37 | 15 (40.5) | 22 (59.5) | 14 (37.8) | 23 (62.2) | 11 (29.7) | 26 (60.3) | 16 (43.2) | 21 (56.8) | ||||
| II | 359 | 157 (43.7) | 202 (56.3) | 180 (50.1) | 179 (49.9) | 162 (45.1) | 197 (54.9) | 143 (39.8) | 216 (60.2) | ||||
| III | 152 | 73 (48.0) | 79 (52.0) | 80 (52.6) | 72 (47.4) | 81 (53.3) | 71 (46.7) | 66 (43.4) | 86 (56.6) | ||||
| Lymph node metastasis | 0.73 | 0.99 | 0.55 | 0.80 | |||||||||
| Negative | 230 | 104 (45.2) | 126 (54.8) | 114 (49.6) | 116 (50.4) | 101 (43.9) | 129 (56.1) | 91 (39.6) | 139 (60.4) | ||||
| Positive | 318 | 141 (44.3) | 177 (55.7) | 160 (50.3) | 158 (49.7) | 153 (48.1) | 165 (51.9) | 134 (42.1) | 184 (57.9) | ||||
| Age (mean ± SD) | 0.5 | 0.15 | 0.66 | 0.33 | |||||||||
| 52.9±6.7 | 52.1±5.8 | 51.2±7.9 | 53.9±5.8 | 52.7±6.7 | 52.2±5.9 | 51.8±8.6 | 52.9±6.2 | ||||||
| Tumor size (mean ± SD) | 0.49 | 0.28 | 0.17 | 0.84 | |||||||||
| 3.0±2.5 | 3.0±2.7 | 3.1±2.7 | 2.9±2.3 | 3.1±3.0 | 2.9±2.6 | 3.0±2.7 | 2.9±2.8 | ||||||
a
The Fisher test was used when N < 5; *P < 0.05.